Efficiency Concerns

Efficiency Concerns

A review conducted by Hazekamp and Grotenhermen in 2010 examined 37 studies conducted from 2005 to 2009 which revealed eight pathologies that showed encouraging outcomes after treatment with marijuana or other synthetic cannabinoids: Neuropathic or chronic pain, experimental pain, multiple sclerosis and spasticity, HIV/AIDS, glaucoma, intestinal dysfunction, nausea, and schizophrenia.  The general conclusion of this review supported the supposition that cannabinoids have a strong therapeutic potential.

The amount of research being conducted into the various uses and effectiveness of cannabinoids and marijuana has grown to the point where an International Journal of Medical Cannabinoids (IJMC) has been created to accommodate the growing need for peer reviewed publications.  While the number of publications available is vast, and provide various conclusions and trends, we have selected some publications that we feel are noteworthy.  If you have any publications you would like us to review please contact us, and come back often to see research that we think is worth investigating.

Selected Articles

Marihuana as Medicine: A Plea for Reconsideration.

Grinspoon,L;   Bakalar, MD James B. Marihuana as Medicine: A Plea for Reconsideration.  JD Journal of the American medical Association, June, 1995

“One of marijuana’s greatest advantages as a medicine is its remarkable safety. It has little effect on major physiological functions. There is 0 known cases of a lethal overdose: on the basis of animal models, the ratio of lethal to effective dose is estimated at 40,000 to 1. By comparison, the ratio is between 3 and 50 to 1 for secobarbital and between 4 and 10 to 1 for ethanol. Marihuana is also far less addictive and far less subject to abuse than many drugs now used as muscle relaxants, hypnotics and analgesics. The chief legitimate concern is the effect of smoking on the lungs. Cannabis smoke carries even more tars and other particulate matter than tobacco smoke. But the amount smoked is much less, especially in medical use.”- Dr. Lester Grinspoon, professor emeritus at Harvard Medical School in the Journal of the American Medical Association, 1995

Smoked Cannabis for Chronic Neuropathic Pain: A Randomized Controlled Trial

Mark A. Ware, MBBS, Tongtong Wang, PhD, Stan Shapiro, PhD, Ann Robinson, RN, Thierry Ducruet, MSc, Thao Huynh, MD, Ann Gamsa, PhD, Gary J. Bennett, PhD, and Jean-Paul Collet, MD PhD CMAJ. 2010 October 5; 182(14): E694–E701.

“Chronic neuropathic pain affects 1%–2% of the adult population and is often refractory to standard pharmacologic treatment. Patients with chronic pain have reported using smoked cannabis to relieve pain, improve sleep and improve mood. Adults with post-traumatic or postsurgical neuropathic pain were randomly assigned to receive cannabis at four potencies (0%, 2.5%, 6% and 9.4% tetrahydrocannabinol) over four 14-day periods in a crossover trial. Participants inhaled a single 25-mg dose through a pipe three times daily for the first five days in each cycle, followed by a nine-day washout period. Daily average pain intensity was measured using an 11-point numeric rating scale. We recorded effects on mood, sleep and quality of life, as well as adverse events.”

Medical Cannabis and Painful Sensory Neuropathy

Igor Grant, MD published in the Virtual Mentor. May 2013, Volume 15, Number 5: 466-469

“Painful peripheral neuropathy comprises multiple symptoms that can severely erode quality of life. These include allodynia (pain evoked by light stimuli that are not normally pain-evoking) and various abnormal sensations termed dysesthesias (e.g., electric shock sensations, “pins and needles,” sensations of coldness or heat, numbness, and other types of uncomfortable and painful sensations). Common causes of peripheral neuropathy include diabetes, HIV/AIDS, spinal cord injuries, multiple sclerosis, and certain drugs and toxins. Commonly prescribed treatments come from drugs of the tricyclic and selective serotonin reuptake inhibitor (SSRI) antidepressant classes, anticonvulsants, opioids, and certain topical agents. Many patients receive only partial benefit from such treatments, and some either do not benefit or cannot tolerate these medications. The need for additional treatment modalities is evident…”

Additional Links and Information

Cognitive Use

An article that explores the potential uses of cannabinoids for cognitive issues such as regenerating brain cells, depression, anxiety, learning and memory and discusses the potential further uses in terms of brain functioning.

Cancer Treatment and Pain

An extensive article from the National Cancer Institute that details the history, research and potential uses for cannabis including anti-tumor effects and use as a pain killer.


Immune System

An article that discusses research regarding how the cannabinoid system regulates the immune system and its potential to help with autoimmune disorders


An article that describes how problems with the endocannabinoid system may have responsibility in causing autism http://www.the-scientist.com/?articles.view/articleNo/35088/title/A-Link-Between-Autism-and-Cannabinoids/

Still Have Questions?



We will answer you fast and easy with any questions you may have!